Gene Targeting

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Gene targeting--the modification of genetic information within a living organism--is revolutionizing modern genetics. It offers new approaches to basic research and holds out the promise of eventual correction of defects in human cells. But what exactly is gene targeting? What is the history of this form of gene manipulation? How is it doe and what are its implications? Gene Targeting provides the nonspecialist with answers to these and related questions. It uses simple, direct language and extensive illustrations to provide a comprehensive review of homologous recombination and gene targeting techniques--the basic principles, methods, applications, and surrounding ethical issues. In the course of the discussion, the book also conveys a sense of the conceptual beauty of molecular biology and the real excitement of scientific discovery.