Teratologie

This comprehensive work delves into the biological foundations of teratogenesis, exploring various aspects of embryonic development and the impact of environmental factors. It covers the compensatory mechanisms of the placenta, the control of embryonic blood vessel formation, and the innervation patterns in limb development. The text examines the spatial relationships of dental structures in NMRI mice and discusses histotypic development and cell differentiation in organoid cultures as in vitro models for teratology. Additionally, it investigates early embryonic neuroepithelium in vitro as a basis for studying teratogenic malformations and presents in vitro screening for embryotoxicity using mouse embryonic stem cell differentiation. The effects of Dimethoate on Wistar rats, along with substrate and enzyme histochemical studies, are analyzed, as well as the impact of trace elements and salicylate effects. The work also addresses the role of structural proteins as targets for teratogenic compounds and explores treatment options for intrauterine growth retardation with nootropics. It discusses the teratoprotective effects of Meclofenoxat in a rat model and examines the teratogenic risks associated with smoking and hormonal contraceptives during early pregnancy. Furthermore, it reviews prenatal infections and their implications, practical experiences in prenatal toxicology testing, and considerations for teratogenic substance