The Coagulation-Inflammation Interface: Coagulation Assembly on Leukocytes

Details recent research on the ability of coagulation proteins/proteases to act as modulators of leukocyte effector functions, and potential implications in host defense and human disease. Coagulation is proposed as a response to injury, integrating the preservation of the hemostatic balance with host defense and immune-inflammatory responses. Part I introduces blood clotting mechanisms and their roles in leukocyte and vascular cell signaling. Part II describes the structure-function relationship of cellular receptors for blood clotting and examines fibrinolytic proteases and their role in signal transduction and effector cell responses. Distributed by Chapman & Hall. Annotation c. by Book News, Inc., Portland, Or.