Future trends in primate toxicology and biotechnology

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The 18th Covance Primate Symposium took place in Münster on October 5-6, 2010, with a record attendance of 143 participants from 16 countries and 57 organizations. This year's focus was on “Future Trends in Primate Toxicology and Biotechnology,” highlighting the relevance of the theme through engaging discussions. Expert speakers addressed four key topics: Proteomics & Genomics, Developmental & Reproductive Toxicology (DART), Safety Pharmacology, and Immunotoxicology. The sequencing of primate genomes has provided insights into the origins of laboratory nonhuman primates, facilitating animal selection based on genetic profiles. In DART, advancements in biopharmaceutical development and updated guidelines have led to more sophisticated studies involving juvenile toxicity evaluations and the use of sexually mature monkeys. Safety pharmacology is evolving with refined experimental designs, emphasizing cardiovascular safety in drug development, prompting updates to guidelines. The session on immunotoxicology explored contemporary regulatory perspectives on monoclonal antibodies, including guideline updates and reviews concerning the immune system and drug development. Notable contributors included B. Anand, J. Beyer, and many others, underscoring the collaborative nature of this important field.