Cologne Atherosclerosis Conference No. 2: Lipids

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The book explores various aspects of lipoprotein metabolism, focusing on synthesis, receptor interactions, and the role of apolipoproteins in hyperlipidaemia. It discusses the genetic basis of apolipoprotein genes and their polymorphisms, employing recombinant DNA technology to investigate polygenic hyperlipidaemia. Key topics include the LDL receptor's role in lipoprotein turnover and the interactions that regulate lipoprotein metabolism. The significance of high-density lipoprotein binding sites on liver membranes is highlighted, along with the function of lipoprotein lipase and organ-specific metabolism of low-density and high-density lipoproteins. The text examines the metabolism of serum high-density lipoprotein apolipoprotein A-IV and the impact of particle size and lipid composition on apolipoprotein transfer. It also addresses the regulation of triglyceride-rich lipoprotein catabolism by lysophosphatidylcholine and the effects of hypercholesterolemic and diabetic serum on LDL degradation. The role of macrophages in lipoprotein degradation and atherosclerosis is analyzed, including their interaction with oxidized lipids. Clinical aspects include the regulation of LDL uptake in various species, familial hypercholesterolemia, and the impact of lifestyle factors on lipoprotein profiles. The book provides insights into the complex interplay between genetic, metabolic, and environmental factors influencing lipoprotein meta