High Performance Liquid Chromatography

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The evolution of liquid column chromatography (LC) since 1969 highlights its status as a key analytical chemistry technique, praised for its simplicity and cost-effectiveness. Despite its potential, the complexity and high cost of commercial instruments have led to a "black box" approach, complicating routine applications. The text warns against relying solely on electronic solutions for separation issues, echoing past challenges in gas chromatography. Additionally, the effectiveness of newly promoted capillary columns remains uncertain without innovative advancements.