Josef Donnerer Boeken

Prevention and treatment of nausea and emesis are important issues in a patients wellbeing in the clinical setting as well as for the outpatient. Various and still partly unresolved pathomechanisms play a role in nausea and emesis in humans. It is therefore important to compare results from preclinical research in animal models with results from clinical studies. This book combines an overview of the preclinical research on antiemetic drugs and state-of-the art reviews on the prevention and treatment of nausea and emesis. Established treatment regimens are compared with new interesting compounds in clinical trials. An up-to-date overview of the selection of antiemetic drugs, of their dosage and route of administration is given for clinical conditions such as emetogenic anti-cancer chemotherapy, radiation therapy, surgery, and hyperemesis gravidarum. The treatment of nausea and emesis in opioid therapy and in motion sickness is equally outlined. Whereas this book should serve the clinician in making the right choice for every patients need, it also pays significant attention to the interests of scientists in the fields of oncology, nutrition, gastroenterology, obstetrics and gynecology as well as anaesthesia.

Neurochemical transmission accounts for the majority of information transfer both in the central and peripheral nervous system. The initial findings centred around the experimental work of the two Nobel Prize winners Sir Henry H. Dale and Otto Loewi as well as Wilhelm Feldberg. Their historical findings opened the door to further investigations and extended the list of neurotransmitters to many others such as amino acids, peptides, purines and nitric oxide. In the first part, the publication provides fascinating insights into the life of the three scientists. Their personality and scientific approach are presented through autobiographical sketches and personal memories by authors. Various comments and details of the atmosphere in the laboratory complete the picture of the conditions at the time. The second part is dedicated to the history of the substances, such as neurotransmitters, their antagonists and analogues. The stories of these substances are presented to the reader in a succinct way, including many anecdotes and unusual events on the way to their therapeutic application.