Respiratory diseases are prevalent in both veterinary and human medicine, and inhalation of aerosols is a common treatment for lung conditions. With increasing prevalence and incidence, there is a growing need for advancements in inhalation therapy to optimize aerosol particle deposition in targeted lung areas. This study focuses on developing and validating a nebulizer system designed for distinct aerosol particle deposition in the lung periphery. Key to achieving this is the manual adjustment of particle size, influencing where particles are deposited intrathoracically. A validation study utilized laser diffraction analysis to measure aerosol particle size across various device settings, including volume flow rate, baffle plate height, and adjustable resistance. Results indicated average particle sizes ranging from 2.38 µm to 4.42 µm, with the volume flow rate having the most significant effect on particle size (p < 0.001). The baffle plate height also significantly affected particle size (p = 2.2%), while adjustable resistance had minimal impact (p = 5.9%), primarily affecting aerosol quantity over time. The developed nebulizer shows promise for inhalation therapy, allowing for targeted lung deposition through volume flow rate adjustments—a unique feature among nebulizer systems. Future enhancements will include filling level control and automatic drug refills, with further studies planned to assess usability for both veter
