Manjul K. Agarwal Boeken

The availability today of a growing number of newly synthesized antihormones has provided a novel means of investigating the molecular actions of hormones and controlling contraception and hormone-dependent dysfunction. The contributors to this volume present the latest developments in the field of hormone antagonists, from both biological and clinical perspectives, with particular emphasis on steroid hormone structure and function. A feature of the book is the discussion of the mechanisms of action and effects of the antiglucocorticoid RU 38486, as well as the potential application of its dissociated parts for the treatment of hormone-dependent conditions including breast cancer and hypertension.

Frontmatter -- Foreword -- Contents -- GENERAL CONSIDERATIONS IN STEROID HORMONE RECEPTOR RESEARCH / Agarwal, M. K. -- STEROID-PROTEIN INTERACTIONS DETERMINED AND INFERRED FROM X-RAY CRYSTALLOGRAPHIC INVESTIGATIONS / Duax, William L. / Fitzgerald, Paula M. D. / Griffin, Jane F. / Rohrer, Douglas C. / Weeks, Charles M. -- MINERALOCORTICOID RECEPTORS / Wambach, Gerhard / Kaufmann, Werner -- GLUCOCORTICOID RECEPTORS / Kalimi, Mohammed / Hubbard, John R. -- ANDROGEN RECEPTORS / Norris, James S. / Smith, Roy G. -- PROGESTERONE RECEPTOR / Moudgil, Virinder K. -- THE ESTROGEN RECEPTOR / Tate, Anna C. / Jordan, V. Craig -- THE 1,25-DIHYDROXYVITAMIN D3 RECEPTOR: Its Physiology and Biochemistry / Eisman, John A. -- EXOGENOUS AND ENDOGENOUS REGULATION OF ADRENERGIC RECEPTORS; APPLICABILITY TO SELECTED CLINICAL PROBLEMS / Bilezikian, John P. / Shane, Elizabeth / Morris, Stephen A. / Steinberg, Susan F. -- ADRENERGIC RECEPTORS AND REGULATION OF ADENYLATE CYCLASE ACTIVITY: METHODOLOGICAL APPROACHES AND INTERPRETATION OF DATA IN TERMS OF RECEPTOR-CYCLASE COUPLING / Limbird, Lee L. -- RECEPTORS FOR OPIATES AND OPIOID PEPTIDES / Childers, Steven R. -- Author Index -- Subject Index -- Backmatter