Marc A. Reymond Boeken

Peritoneal dissemination is a prevalent pathway for cancer metastasis, and administering chemotherapy directly into the peritoneal cavity offers significant advantages. Intraperitoneal (IP) chemotherapy achieves much higher drug concentrations in the abdominal cavity compared to intravenous (IV) methods. Clinical studies indicate a survival benefit for IP chemotherapy across various tumor types, including ovarian, gastric, and colorectal cancers. Despite its growing acceptance, IP chemotherapy faces challenges due to increased toxicity and limited efficacy stemming from poor drug distribution and tissue penetration. A novel approach, pressurized intraperitoneal aerosol chemotherapy (PIPAC), utilizes a pressurized aerosol of cytotoxics delivered laparoscopically. This method establishes a normothermic capnoperitoneum at 12 mmHg, where a cytotoxic solution is nebulized into the abdominal cavity for 30 minutes before being suctioned out. This aerosol application ensures uniform distribution of the drug and creates an artificial pressure gradient that enhances drug penetration while maintaining low plasma concentrations. Initial clinical studies in ovarian, gastric, colorectal cancers, and peritoneal mesothelioma show promising tumor response rates and minimal side effects. Ongoing larger trials aim to validate these findings and explore broader applications.

This is the most talked about subject in laparoscopic surgery today. At every meeting in surgery and oncology at least one or two sections involve this topic. This book allows the reader an organized insight into the different pathogenic mechanisms of port-site recurrences, notably as to where the cells from which the secondary tumour arises come from, how they are dispersed, and how local effects in the port-site wound can favor implantation. Moreover, the book contains practical well illustrated guidelines to show preventive measures applicable by any surgeon. These can reduce substantially the incidence of port-site recurrence, allowing for a safer application of minimally invasive surgery in cancer. All or most surgical units working in this field world wide have contributed to this book. TOC: Definition.- Abdominal wall recurrences in open surgery.- Port site recurrences in open surgery.- Port site recurrence in thoracoscopic surgery.- Pathogenesis.- Prospective randomized trials.- Natural history.- Prevention.- Treatment.- Perspectives.

Jeder chirurgische Weiterbildungsassistent muss Operationstechniken erlernen. Hier werden die wichtigsten Eingriffe Schritt für Schritt anschaulich in Bildern dargestellt. Inklusive einiger neuer Techniken, z. B. videoassistierte OP, gastric banding etc. Zahlreiche Abbildungen stammen aus der bewährten „Chirurgischen OP-Lehre“ von Breitner. Aus dem Inhalt: Chirurgie Kopf und Hals, Thoraxchirurgie, Abdominalchirurgie, Chirurgie der Oberfläche, Traumatologie, Transplantationschirurgie, Gefäßchirurgie, Plastische Chirurgie/Handchirurgie