Perspectives in antiinfective therapy

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This comprehensive work delves into various aspects of infectious disease treatment and research, beginning with the historical context of bacteriological studies and Robert Koch's influential lecture in 1890. It explores classical antibacterial drug mechanisms, highlighting the clonal nature of resistance in penicillin-resistant pneumococci and the complexities of antibiotic uptake in Gram-negative bacteria. The text further examines the inhibition of protein biosynthesis and DNA gyrase, detailing bacterial sensitivity and clinical resistance to 4-quinolones. Additionally, it covers nonbacterial anti-infective drugs, antiretroviral compounds, and the effects of drugs on lipids and membrane integrity in fungi. The mechanisms of action for antimalarial drugs and the pathogenic microbial mechanisms vulnerable to drug application are also discussed. The work addresses drug resistance, including transposon transfer and bacterial proteins involved in antimicrobial resistance. Further topics include pharmacology, drug delivery methods like liposomes, and the role of host determinants in anti-infective chemotherapy. It highlights the challenges of neutropenia, modulation of host flora, and passive immunotherapy lessons. The text concludes with discussions on new diseases, current knowledge of Chlamydia TWAR, and the status of antiviral chemotherapy for genital herpes. It emphasizes modern strategies in drug design, future challenge