Experimental and genetic rat models of chronic renal failure

Animal models of chronic renal failure are useful research tools only when the selected model lends itself to providing the answer to a particular question. This book presents a broad spectrum of experimental and genetic rat models of chronic renal failure in such a way that their advantages, disadvantages and special features are clearly indicated. The information provided enables researchers to choose the appropriate model. This is especially important in tne testing of therapeutic modalities. The book not only describes the induction and progression of renal failure, but also discusses factors, intrinsic to each model, which could considerably influence results. In addition, problems in the measurement of blood pressure and glomerular filtration rate are considered in detail.