Tissue engineering

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This special volume on tissue engineering reflects its emergence as a core discipline in modern biomedical engineering, highlighting the synergies between biotechnology and biomedicine. It aims to provide a biotechnology-driven perspective on cell engineering fundamentals and their significance in producing functional tissues. The volume offers an overview of state-of-the-art technologies, emphasizing current applications in developing cell-based therapies for human diseases. Contributions from leaders and experts span various fields, including biomaterials, bioreactors, gene delivery, and metabolic engineering. Reviews focus on biochemical processes underlying cell function, such as signaling, growth, differentiation, and communication. The topics cover cellular and non-cellular components, assembly, and the evaluation and optimization of tissue function, alongside integrated reactor or implant system development for research and clinical applications. Many reviews illustrate how biochemical engineering methods help produce and characterize novel materials, such as genetically engineered natural polymers and synthetic scaffolds with cell-type specific attachment sites or inductive factors. These unique properties enhance control over tissue development and architecture.