Therapeutic plasma exchange and selective plasma separation methods

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The fourth edition provides a comprehensive overview of therapeutic apheresis (TA), detailing semi- and selective methods available today. It covers all methods, their functions, indications, clinical outcomes, criticisms, and future perspectives. Spanning 580 pages, it includes 117 tables, 85 figures, and 3380 references across six chapters. Key topics include historical highlights, unselective, semi-selective, and selective separation procedures, complications, side effects, and clinical results across various diseases, including pediatric applications. The edition discusses advanced methods like cascade-filtration, cryofiltration, plasmaperfusion, fibrinogen-adsorption, and various immunoadsorption techniques, along with LDL-apheresis and systems such as BioLogic-DTPP, MARS, and Prometheus. It highlights TA's role in organ transplantation, particularly for ABO incompatible transplants, enhancing strategies for patients with high immunization levels and expanding living donation options. Clinical application committees have graded diseases accepted for TA, influencing treatment routines. While TA offers benefits like eliminating pathological substances, it also presents challenges such as unselective protein removal, potential complications, and high costs. The authors emphasize the need for clear indications for TA, especially as healthcare resources decline. This edition serves as a vital resource for physicians, nurses, s