Palladium-catalyzed coupling reactions

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This handbook serves as a comprehensive reference, consolidating significant practical issues in selected topics while highlighting recent achievements. It addresses both homogeneous and heterogeneous catalysis, with a unique focus on crucial aspects like various reaction media, microwave techniques, and catalyst recycling. Key modern coupling reactions are thoroughly discussed, emphasizing areas with future potential such as continuous flow systems, water as a reaction medium, and catalyst immobilization. The inclusion of large-scale applications in the pharmaceutical industry makes it particularly valuable for industrial chemists. Key topics covered include: an introduction to palladium-catalyzed cross-coupling reactions; high-turnover heterogeneous palladium catalysts; the use of magnetically separable nanocatalysts; ordered porous solids as support materials; polymer-supported catalysts; ionic liquids; aqueous media; microwave-assisted synthesis in coupling reactions; catalyst recycling in carbon-carbon coupling reactions; the nature of true catalytic species in reactions with heterogeneous palladium precatalysts; continuous flow systems; and large-scale applications in the pharmaceutical sector. This resource is designed for those interested in the latest advancements and practical applications in catalysis.