Analyzing rare variants in complex diseases

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This special issue discusses the possible strategies and statistical methods that can be used to evidence the role of rare genetic variants in complex traits. Some papers review the latest developments made in this field while others propose some novel and original methods to find these variants and detect gene-environment interactions. Bringing together the experiences and thoughts of recognized world experts in the field, this is a must-read issue for anyone who wants to embark on a next-generation sequencing project.