Autoantibodies in organ specific autoimmune diseases

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Six years have passed since the first edition of this diagnostic reference, and the field of autoantibodies continues to evolve rapidly. New studies have emerged, revealing novel autoantibodies and their clinical associations, alongside advancements in diagnostic techniques and the identification of new autoimmune disease entities. For instance, agonistic and inhibiting autoantibodies targeting receptor structures have enhanced our understanding of autoimmune mechanisms. Additionally, recently identified autoantibody specificities have brought attention to unique autoimmune conditions, including subtypes of autoimmune encephalopathies and IgG4-mediated paranodopathy. New assays for autoantibody detection have been developed and integrated into routine diagnostics, while recent evaluation studies and meta-analyses have prompted a reassessment of the clinical significance of certain autoantibody specificities. These developments necessitated an updated volume to serve as a comprehensive reference for the serological diagnosis of autoimmune diseases and to support clinically relevant autoimmune research. We appreciate the valuable feedback from our readers since the last edition, which has contributed to this timely update.