Application and Synthesis of Small Quinoline Derivatives

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The book presents a green and efficient one-pot microwave irradiation method for synthesizing quinoline-4-carboxylic acids using the non-hazardous p-TSA catalyst. This protocol boasts high product yields and purity, significantly reduced reaction times, and eliminates hazardous solvents, aligning with green chemistry principles. It details the synthesis of compounds 4a-4p and their biological activity testing, with molecular docking studies indicating their compatibility with protein active sites. Compound 4c was highlighted for further molecular dynamics analysis.