The Mast Cell

Mast cells are ancient immune cells found throughout the human body, particularly near connective tissues and surfaces exposed to the environment. They play a crucial role in initiating defense mechanisms against foreign invaders and are central to type I hypersensitivity reactions. Beyond allergic responses, mast cells are involved in host defense against various pathogens and contribute to both acquired and innate immunity. Additionally, they have significant non-immunological functions, influencing tissue homeostasis, remodeling, fibrosis, and angiogenesis.