Viral Interference of GB Virus C and Human Immunodeficiency Viruses

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Co-infection of HIV with GB Virus C (GBV-C) presents a paradox where long-term GBV-C viremia correlates with improved survival rates in HIV patients, despite the lack of definitive causal evidence. Research indicates that GBV-C may inhibit various HIV strains through complex mechanisms, including specific proteins that block HIV entry and replication. Additionally, GBV-C induces antibodies that neutralize HIV, suggesting potential avenues for new drug and vaccine development. This interplay between GBV-C and HIV highlights important clinical implications for treatment strategies.