Designing, Synthesis and Molecular modeling of Novel Compounds

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The book delves into the complexity of breast cancer, highlighting its molecular, histopathologic, and clinical heterogeneity. It discusses how whole-genome analysis has identified five distinct subtypes—Luminal A, Luminal B, HER2 over-expression, Basal-like, and Normal-like—each with unique characteristics and clinical implications. Additionally, it explains how these subtypes can be categorized using immunohistochemical analysis, emphasizing their correlation with gene expression profiles, variations in treatment responses, and patterns of recurrence.