Structural Insights Into Coronavirus Binding to Host Amino Peptidase

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The book delves into the biology of coronaviruses, highlighting their evolution from veterinary concerns to significant human health threats due to recent outbreaks. It explains the viruses' ability to adapt and utilize various cell surface receptors for entry, particularly focusing on the role of aminopeptidase N (APN) as a key entry point. APN, a multifunctional enzyme linked to various physiological processes and cancer, is examined for its distribution across tissues and its altered expression in tumors, offering insights into the complexities of CoV infection mechanisms.