The discovery of endothelin-1 marks a pivotal moment in medical research, opening avenues for understanding its production, physiological roles, and connections to various health issues like renal failure and heart conditions. This book serves as a primer for newcomers to the field, providing insights into the excitement surrounding endothelin research. It aims to bridge the gap for those interested in the growing body of literature on endothelins, highlighting their significance in both normal physiology and pathological states.
"Another damned, thick, square book! Always scribble, scribble, scribble! Eh! Mr. Gibbon?" From the Literary Memoirs of Willi am, DUKE OF GLOUCESTER, 1743-1805 The foreword of any book is probably the most difficult to write -not only because it stands at the beginning of an exercise in writing and logic but because it is in this chapter that areader can expect to find a clear and unambiguous explanation of the author's reason for writing the book and why some subject matter has been included and other subject matter excluded. Potential readers ofthis book may not have an inclination to question why some subject matter has been excluded but instead may wonder why another book on calcium antagonists has been published. However, it is arguable with some force that there have been at least three recent developments in the field of calcium antagonism which provide more than adequate support for the view that another book on this topic is warranted. These developments (i) an improved understanding of the chemical structure, mode of action and architecture of the voltage-activated, calcium antagonist-sensitive calcium channels and their associated calcium-antagonist specific binding sites; (ii) a more accurate appreciation ofhow and when the calcium antagonists should be used in the management of a variety of clinical dis orders including cerebral ischaemia atherosclerosis, "mild" ischaemic heart disease, ventricular hyper trophy, impaired ventricular relaxation and hypertension (to name but a few), and (iii) the emergence of a second generation of calcium antagonists.
Inhaltsverzeichnis1. Brauchen wir überhaupt andere Calciumantagonisten?.2. Calcium und seine Bedeutung für die biologischen Systeme.3. Transport durch die Zellmembran.4. Spannungsgesteuerte, auf Calciumantagonisten ansprechende Calciumkanäle: Struktur, Zusammensetzung und Bindungsstellen für Calciumantagonisten.5. Chemie der Calciumantagonisten.6. Amlodipin, ein Calciumantagonist mit lang anhaltender Wirkung und mit einem ungewöhnlichen Bindungsprofil.7. Pharmakokinetische Eigenschaften von Amlodipin.8. Vasoselektivität von Amlodipin.9. Bedingungen, die das pharmakokinetische Profil von Amlodipin beeinflussen.10. Calciumantagonisten und die Niere.11. Calciumantagonismus und das ischämische Herz: Spielt der Calciumantagonismus hier eine Rolle?.12. Calciumantagonismus und das „stunned“ Herz: Üben vasoselektive Calciumantagonisten eine Schutzwirkung aus?.13. Amlodipin und das „hibernating“ Myokard: Könnte sich die Substanz hier als wirksam erweisen?.14. Calciumantagonisten und die Behandlung der Hypertonie.15. Antiatherogenes Potential der Calciumantagonisten einschließlich Amlodipin.16. Amlodipin und der Koronarkreislauf: Ist Amlodipin ein wirksames Mittel gegen Angina pectoris?..17. Calciumantagonisten und die Herzinsuffizienz.18. Nebenwirkungen der Behandlung mit Calciumantagonisten: Verhält sich Amlodipin anders?.19. Zukunftsperspektiven des Calciumantagonismus.Literatur.
