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Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.

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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy

Taal
Jaar van publicatie
2014
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Ondertitel
Synthesis and Biological Evaluation
Taal
Engels
Auteurs
Colm Duffy
Jaar van publicatie
2014
Formaat
Paperback
Aantal pagina's
152
ISBN13
9783642438929
Aantekening
Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.