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Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Taal
- Jaar van publicatie
- 2012
- product-detail.submit-box.info.binding
- (Hardcover)
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- Ondertitel
- Synthesis and Biological Evaluation
- Taal
- Engels
- Auteurs
- Colm Duffy
- Uitgever
- Springer Berlin Heidelberg
- Jaar van publicatie
- 2012
- Formaat
- Hardcover
- Aantal pagina's
- 152
- ISBN13
- 9783642246319
- Reeks
- Springer Theses
- Tags
- Non-fictie
- Aantekening
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.